Characterization Formulation and in Vitro Assesment of Pulsatile Drug Delivery of Montelukast Sodium

The Montelukast pulsatile delivery system was created with the goal of delivering drug to colon for successful treatment nocturnal asthma. microspheres were sealed within insoluble hard gelatin capsule body an erodible hydrogel plug create a time delayed capsule. Emulsion solvent evaporation used make microspheres. Based on dissolving tests, optimised microsphere formulations designed. entire device enteric coated in order overcome variability gastric emptying and achieve colon-specific delivery. (HPMC K100 lactose 1:1 ratio) hardness 4.5kg/cm2 weight 100 mg placed opening found be effective delaying release small intestinal fluid, ejecting into colonic releasing fluid after 5-hour lag time. Three medium pH 1.2, 7.4, 6.8 employed consecutively imitate fluctuations along GI tract. medication polymer had no interaction, according FTIR analysis. 1:4 ratio longest all formulations, lasting 12 hours. results showed that is capable programmable period treating Keywords: Montelukast, plugs, delivery, asthma,